Creatine Atp

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Posted by admin | Posted in Uncategorized | Posted on 25-08-2011

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phosphocreatine + ADP = creatine + ATP PLEASE EXPLAIN!!?

what is each thing.. what do ADP and ATP stand for.. how are they converted? how does this result in muscle contraction?? Trying to understand this for a project but makes zero sense right now..thanks in advance

ATP (adenosine triphosphate) is the cell’s main source of energy. It is used in muscle to make the troponin RELEASE the protein filament. It is also used to power other processes in the cell, such as keeping the electrochemical gradient, which is vital for muscle contraction. when you use your muscles, the stores of ATP are used up within seconds. this can lead to muscle weakness and fatigue. ATP is a molecule with three phosphates in a line connected to the molecule adenosine. the last of these phosphates is the high energy bond and is responsible for the release of energy. when ATP is used this phosphate is cleaved, leaving ADP, or adenosine diphosphate, which is simply ATP without that last high energy phosphate.
so when you have an energy yielding reaction you will have ATP converted to ADP + phosphate + some kind of work done. The body’s main way of creating ATP is the metabolism of sugar (glucose). this is efficient, but is limited by the speed of the many reactions needed for it to take place. a faster way of producing ATP is by adding a phosphate to ADP. this can be achieved by phosphocreatine. this phosphocreatine acts as a kind of energy reserve in the muscle cell. when ATP is down, phosphocreatine will donate that phosphate to ADP, yielding ATP and providing the cell with energy.
here is a depiction of the reactions taking place. a / represents a bond and pi represents phosphate.
adenosine/pi/pi/pi (high energy ATP) = adenosine/pi/pi (low energy ADP) + phosphate + work
the chemical potential energy of ATP has been transformed into mechanical work and yields a low energy ADP in its place
adenosine/pi/pi (low energy ADP) + creatine/pi (the energy reserve) = Adenosine/pi/pi/pi (high energy ATP)
the phosphate has been transferred from the creatine to the ADP to yield high energy ATP.
the reaction of ADP + phosphate = ATP is not spontaneous without the phosphocreatine. this is because it requires a great amount of energy to create that high energy bond. you can think of the phosphocreatine as a catalyst in that sense, but it is not one in the technical sense.

Also, in the final equation with the phosphocreatine donating that phosphate, the final product is not creatine, but rather its metabolite creatinine. If it were creatine, it could be reused. this is not the case as we need to eat and synthesize creatine to replace what is lost during this reaction.
I hope this has helped. i was just reading about creatine’s effects earlier today. It seems to have many uses in disease states where the muscles lose their strength, along with use in neurological disorders, such as huntington’s and parkinson’s diseases. if you want some info on these i would suggest finding a search engine for scholarly journals, such as google.com/scholar and searching for creatine supplement. this will come up with some good results. check out the meta-analyses.

Prolab Creatine Monohydrate